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GB12575 Anti -Chk2 Mouse mAb Antibody

Immunogen: Recombinant protein corresponding to Mouse Chk2
Isotype: IgG
Purity: Affinity purification
ul:
  • GB12575
  • Servicebio

Description

Product Information


Description

Chk2 mouse monoclonal

Protein full name

Serine/ threonine-protein kinase Chk2

Synonyms

CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2

Immunogen

Recombinant protein corresponding to Mouse Chk2

Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus

Uniprot ID

O96017




Applications


Applications

IHC

IF

Species

Human

Human

Dilution

1: 300-1: 600

1: 150-1: 300

Positive tissue

colon, colon cancer,stomach cancer

colon, colon cancer,stomach cancer




Background


CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is mainly involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. When DNA undergoes a double-strand break, CHK2 is activated. Specifically, DNA damage-activated phosphatidylinositol kinase family protein (PIKK) ATM phosphorylates site Thr68 and activates CHK2. Once activated, CHK2 phosphorylates downstream targets including CDC25 phosphatases, responsible for dephosphorylating and activating the cyclin-dependent kinases (CDKs). Thus, CHK2’ s inhibition of the CDC25 phosphatases prevents entry of the cell into mitosis.





Images


Immunohistochemistry analysis of paraffin-embedded human colon using
Chk2 (GB12575) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded human colon cancer
using Chk2 (GB12575) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded human stomach cancer
using Chk2 (GB12575) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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