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Anti -ERK1/2 Rabbit PAb For IHC Primary Antibody Polyclonals

Specification:50UL
  • GB13003
  • Servicebio
  • Servicebio

Description

Product Information

 

Description ERK1/2 rabbit polyclonal
Protein full name ERK1/2
Synonyms Mitogen-activated protein kinase 3, MAP kinase 3,MAPK 3,ERT2, Extracellular signal-regulated kinase 1, ERK-1,Insulin-stimulated MAP2 kinase,MAP kinase isoform p44, p44-MAPK,Microtubule-associated protein 2 kinase,p44-ERK1,MAPK3,ERK1,PRKM3
Immunogen Synthetic peptide, corresponding to amino acids 320-370 of Human ERK1
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus
Uniprot ID P27361, P28482

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human, Mouse, Rat 1: 50-1: 200 eye, hepatoma, cervix, lymph

 


 

Background

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr- Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos-phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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