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Anti -ERK1/2 Rabbit PAb For IHC Primary Antibody Polyclonals

  • GB13003
  • Servicebio
  • Servicebio


Product Information


Description ERK1/2 rabbit polyclonal
Protein full name ERK1/2
Synonyms Mitogen-activated protein kinase 3, MAP kinase 3,MAPK 3,ERT2, Extracellular signal-regulated kinase 1, ERK-1,Insulin-stimulated MAP2 kinase,MAP kinase isoform p44, p44-MAPK,Microtubule-associated protein 2 kinase,p44-ERK1,MAPK3,ERK1,PRKM3
Immunogen Synthetic peptide, corresponding to amino acids 320-370 of Human ERK1
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus
Uniprot ID P27361, P28482





Applications Species Dilution Positive Tissue
IHC Human, Mouse, Rat 1: 50-1: 200 eye, hepatoma, cervix, lymph




The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr- Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos-phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.









Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.



NOTE: This product is intended for research only.

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