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Anti -P-JNK1/2/3Rabbit PAb for IHC Primary Antibody

specification:50uL
  • GB13019-1
  • Servicebio
  • Servicebio

Description

Product Information

 

Description P-JNK1/2/3 rabbit polyclonal
Protein full name JNK1/2/3 (phospho-T183) polyclonal antibody
Synonyms JNK 46, JNK 55, JNK, JNK1, JNK1A2, JNK2, JNK21B1/2, JNK2ALPHA, JNK2B, JNK2BETA, JNK3, JNK3A, MAP 8
Immunogen Synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Threonine 183.
Isotype IgG
Purity Affinity purification
Subcellular location Cytoplasm, Nucleus
Uniprot ID P45983, P45984, P53779

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human, Mouse, Rat 1: 50-1: 200 colorectal carcinoma

 


 

Background

The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).

 


 

Images

 

 


 

Storage

 

Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Storage Buffer Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

 


 

NOTE: This product is intended for research only.

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