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Anti -P53 Mouse MAb for Human IHC

Specification:50uL
  • GB13029-2
  • Servicebio
  • Servicebio

Description

Product Information

 

Description P53 mouse monoclonal
Protein full name TP53
Synonyms BCC7, LFS1, TRP53
Immunogen Recombinant human wild-type p53 protein.
Isotype IgG
Purity Ascites
Subcellular location Cytoplasm, Nucleus
Uniprot ID P04637

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human 1: 50-1: 400 mammary cancer

 


 

Background

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

 


 

Images

 

 


 

Storage

 

Storage 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
Storage Buffer Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

 


 

NOTE: This product is intended for research only.

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