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Anti -KI67 mouse mAb For Human IHC

Specification:50uL
  • GB13030-M-2
  • Servicebio
  • Servicebio

Description

Product Information

 

Description KI67 mouse monoclonal
Protein full name Proliferation marker protein Ki-67
Synonyms KI67_HUMAN, KIA, Marker of proliferation Ki-67, MIB 1, MIB, MKI67, PPP1R105
Immunogen  
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus
Uniprot ID P46013

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human 1: 50-1: 200 tonsil

 


 

Background

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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