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Anti -CD8 Mouse MAb For Human IHC Monoclonal Antibody

specification:50UL
  • GB13068-2
  • Servicebio
  • Servicebio

Description

Product Information

 

Description CD8 Mouse monoclonal
Protein full name T-cell surface glycoprotein CD8 alpha chain
Synonyms CD8A, CD8, Leu2, MAL, p32,CD8a molecule, CD8 alpha
Immunogen Recombinant fragment corresponding to Human CD8 alpha
Isotype IgG
Purity Affinity purification
Subcellular location Cell membrane,Secreted
Uniprot ID P01732

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human 1: 200-1: 400 tonsil

 


 

Background

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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