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Anti -ERa Rabbit PAb for IHC IF Polyclonal Antibody

Specification:50uL 
  • GB13205
  • Servicebio
  • Servicebio

Description

Product Information

 

Description ER-alpha rabbit polyclonal
Protein full name Estrogen Receptor-alpha
Synonyms DKFZp686N23123, ER alpha, ER, ER-alpha, Era, ESR, ESR1, ESRA, Estradiol receptor, Estrogen nuclear receptor alpha, Estrogen receptor 1
Immunogen A synthesized peptide derived from human Estrogen Receptor-alpha, corresponding to a region within C-terminal amino acids.
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus, Cytoplasm
Uniprot ID P03372

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC、IF Human, Mouse, Rat 1: 50-1: 200 brain, breast, breast adenocarcinoma

 


 

Background

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter.

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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