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Anti -IKB Alpha Rabbit PAb For Western Blot Lab Research Antibody

  • GB111509
  • Servicebio
  • Servicebio


Product Information


IKB alpha rabbit polyclonal

Protein full name

NF-kappa-B inhibitor alpha


NFKBIA, IKBA, MAD-3, NFKBI,NFKB inhibitor alpha


KLH conjugated Synthetic peptide corresponding to Rat IKB alpha.




Affinity purification

Predicted MW.

36 kDa

Observed MW.

36 kDa

Uniprot ID

P25963, Q9Z1E3, Q63746





Positive tissue


Human, Mouse, Rat

1: 500-1: 1000

spleen, skin, lung


Three major forms of IKB like molecules have been identified and each is characterised by multiple copies of ankyrin repeats. IKB alpha and IKB beta appear to be the major regulatory forms of IKB in most cells. These proteins interact with p65 or cRel containing forms of NFkB and block nuclear import by masking the nuclear localisation sequences of NFkB. The activation of NFkB involves the inducible phosphorylation and subsequent degradation of IKB. Immunoblotting easily detects the hyperphosphorylated forms of IKB alpha, but not phosphorylated IKB beta. Interestingly, IKB alpha and IKB beta mediate different NFkB responses. IkB alpha appears to control more transient activation of NFkB in response to an inducer, while IKB beta controls a persistent response. Bcl3 interacts with p50 and p52 containing forms of NFkB, but rather than being an inhibitor it appears to function to stimulate transcription. The degradation of IKB is confirmed by immunoblotting.



Western blot analysis of IKB alpha (GB13212-1) at dilution of 1:1000.

Lane 1: HeLa cell lysate

Lane 2: HepG2 cell lysate

Lane 3: A431 cell lysate

Lane 4: Mouse spleen tissue lysate

Lane 5: Mouse skin tissue lysate

Lane 6: Mouse lung tissue lysate

Lane 7: Rat spleen tissue lysate

Lane 8: Rat skin tissue lysate

Lane 9: Rat lung tissue lysate


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE: This product is intended for research only.

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