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Anti -Cdk4 Rabbit PAb for WB IHC Colon

Specification:50uL
  • GB13238
  • Servicebio
  • Servicebio

Description

Product Information

 

Description

Cdk4 rabbit polyclonal

Protein full name

Cyclin-dependent kinase 4

Synonyms

Cell division protein kinase 4, PSK-J3, CDK4

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CDK4 (NP_000066.1).

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Membrane, Nucleus

Predicted MW.

34 kDa

Observed MW.

20/33 kDa

Uniprot ID

P11802, P30285

 


 

Applications

 

Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse

1: 500-1: 2000

lung

IHC

Human

1: 50-1: 200

colon

IHC

Human

1: 50-1: 200

A549

 


 

Background

 

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

 


 

Images

 

   
   

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE: This product is intended for research only.

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