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Anti -RUNX2 Rabbit pAb For Western Blot

Specification:50uL
  • GB13264
  • Servicebio
  • Servicebio

Description

Product Information



Description

RUNX2 rabbit polyclonal

Protein full name

Runt-related transcription factor 2

Synonyms

AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA, runt related transcription factor 2

Immunogen KLH conjugated Synthetic peptide corresponding to Human RUNX2.
Isotype IgG
Purity Affinity purification

Predicted MW.

57 kDa

Observed MW.

57 kDa

Uniprot ID

Q08775, Q13950, Q9Z2J9




Applications



Applications

WB

Species

Human, Mouse,Rat

Dilution

1:500-1:2000

Positive tissue

heart, testis, cartilage




Background



This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.




Images



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Western blot analysis of RUNX2 (GB13264) at dilution of 1:1000.

Lane 1: PC-3 cell lysate

Lane 2: HL-60 cell lysate

Lane 3: HCT116 cell lysate

Lane 4: Mouse heart tissue lysate

Lane 5: Mouse testis tissue lysate

Lane 6: Mouse cartilage tissue lysate

Lane 7: Rat heart tissue lysate

Lane 8: Rat testis tissue lysate

Lane 9: Rat cartilage tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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