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Anti -Cyclin E1 Rabbit pAb For Western Blot Primary Antibody

Specification:50uL
  • GB13305
  • Servicebio
  • Servicebio

Description

Product Information


Description

Cyclin E1 rabbit polyclonal

Protein full name

G1/S-specific cyclin-E1

Synonyms

CCNE1, CCNE, pcyclin E1

Immunogen

KLH conjugated Synthetic peptide corresponding to rat Cyclin E1.

Isotype

IgG

Purity

Affinity purification

Predicted MW.

47 kDa

Observed MW.

47 kDa

Uniprot ID

P24864,Q61457,P39949




Applications


applications

species

dilution

Positive tissue

WB

Human, Mouse, Rat

1: 1000-1: 3000

brain, testis, liver




Background



The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.




Images



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Western blot analysis of Cyclin E1 (GB13305) at dilution of 1:3000.

Lane 1: HeLa cell lysate

Lane 2: A549 cell lysate

Lane 3: HepG2 cell lysate

Lane 4: Mouse brain tissue lysate

Lane 5: Mouse testis tissue lysate

Lane 6: Mouse liver tissue lysate

Lane 7: Rat brain tissue lysate

Lane 8: Rat testis tissue lysate

Lane 9: Rat liver tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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