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Anti -LC3 Rabbit PAb for IHC Polyclonal Antibody

specification:50uL 
  • GB13431
  • Servicebio
  • Servicebio

Description

Product Information

 

Description LC3A/B rabbit polyclonal
Protein full name Microtubule-associated proteins 1A/1B light chain 3
Synonyms LC3, LC3A, LC3A/B, LC3B, MAP1A/MAP1B LC3 A, MAP1A/MAP1B light chain 3 A, MAP1ALC3, MAP1BLC3, MAP1LC3A, MAP1LC3A/B, MAP1LC3B
Immunogen LC3 fusion protein Ag6144
Isotype IgG
Purity Affinity purification
Subcellular location Cytoskeleton
Uniprot ID Q9GZQ8, Q9H492, Q62625, Q6XVN8, Q9CQV6, Q91VR7

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human, Mouse, Rat 1:300-1:1200 brain, lung

 


 

Background

LC3, also known as microtubule-associated protein 1 light chain 3 (MAP1LC3), is a mammalian homolog of the yeast Atg8p (autophagy-related 8 protein) that is involved in autophagy process. Three isoforms of LC3 exist as LC3A,LC3B, and LC3C. LC3 is first synthesized as pro-LC3, and undergoes C-terminal cleavage to yield a cytosolic precursor known as LC3-I. During autophagy LC3-I is subsequently conjugated to PE lipid as lipidated form: LC3-II. The lipidated form migrates faster on SDS-PAGE gel. The increased the level of LC3-II has been widely used as autophagy marker. This antibody recognizes both LC3-I and LC3-II.

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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