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Anti -PDL1 mouse mAb for IHC IF

specification:50uL
  • GB14132
  • Servicebio
  • Servicebio

Description

Product Information

 

Description PDL1 mouse monoclonall
Protein full name Anti-PD-L1 antibody
Synonyms B7 H, CD274, MGC142294, PD1L1
Immunogen Recombinant fragment corresponding to Human PD-L1 aa 39-191.
Database link
Isotype IgG
Purity Protein A/G purified
Subcellular location Cell membrane and Endomembrane system.
Uniprot ID Q9NZQ7

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human, Mouse, Rat 1: 100-1: 200 lung SCC, cervical carcinoma, breast carcinoma

 


 

Background

Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410). As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443, PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).

 


 

Images

 

 


 

Storage

 

Storage Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer Preservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA

 


 

NOTE: This product is intended for research only.

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