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Anti -Foxp3 Rat mAb For IHC Cancer Research

Specification:50uL
  • GB13445
  • Servicebio
  • Servicebio

Description

Product Information

 

Description Foxp3 rat Monoclonal
Protein full name Forkhead box protein P3
Synonyms IID, AIID, DIETER, DIETER, Forkhead box P3, Forkhead box protein P3, FOXP3delta7
Immunogen  
Isotype IgG
Purity Affinity purification
Subcellular location Nucleus
Uniprot ID Q9BZS1, Q99JB6

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Mouse, Rat 1: 50-1: 200 kidney

 


 

Background

Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG).

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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