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GB13457 Anti -NLRP3 Rabbit pAb Polyclonal

Immunogen: Synthetic peptide within Human NLRP3 aa 1-50 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Isotype: IgG
Purity: Affinity purification
ul:
  • GB13457
  • Servicebio

Description

Product Information

 

DescriptionNlrp3 rabbit polyclonal
Protein full nameNLR Family Pyrin Domain Containing 3
SynonymsAGTAVPRL antibody
AII/AVP antibody
Angiotensin/vasopressin receptor AII/AVP like antibody
ImmunogenSynthetic peptide within Human NLRP3 aa 1-50 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
IsotypeIgG
PurityAffinity purification
Predicted MW.118kDa
Observed MW.118kDa
Uniprot IDQ96P20

 


 

Applications

 

ApplicationsSpeciesDilutionPositive Tissue
WBHuman, Mouse, Rat1: 500-1: 5000Raji, SiHa, MDA-MB-231, spleen, thymus

 


 

Background

NALP3, also named as C1orf7, CIAS1 and PYPAF1, belongs to the NLRP family. NALP3 may function as an inducer of apoptosis. It interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling.NALP3 inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. NALP3 activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1) which also known as familial cold urticaria.

 


 

Storage

 

StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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