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GB13473 Anti -IL-10 Mouse pAb Mouse Derived Polyclonal Antibody

Immunogen: IL-10 fusion protein Ag14870
Isotype: IgG
Purity: Affinity purification
ul:
  • GB13473
  • Servicebio

Description

Product Information

 

DescriptionIL-10 Mouse polyclonal
Protein full nameIL-10
SynonymsCSIF, IL 10, IL10, IL-10, IL10A, interleukin 10, TGIF
ImmunogenIL-10 fusion protein Ag14870
IsotypeIgG
PurityAffinity purification
Predicted MW.21 kDa
Observed MW.22 kDa
Uniprot IDP22301

 


 

Applications

 

ApplicationsSpeciesDilutionPositive Tissue
WBHuman, Rat1: 2000-1: 20000cell lines, including T-cells, macrophages, mast cells

 


 

Background

Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

 


 

Storage

 

StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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