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GB13483 Anti -pro Caspase-1 + p10 + p12 Rabbit pAb

Immunogen: Recombinant protein corresponding to Mouse pro Caspase-1 + p10 + p12
Isotype: IgG
Purity: Affinity purification
ul:
  • GB13483
  • Servicebio

Description

Product Information

 

Descriptionpro Caspase-1 + p10 + p12 rabbit polyclonal
Protein full namecaspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
SynonymsCASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, Interleukin 1 beta convertase, p10, p20, P45
ImmunogenRecombinant protein corresponding to
Mouse pro Caspase-1 + p10 + p12
IsotypeIgG
PurityAffinity purification
Predicted MW.45 kDa
Observed MW.45, 42, 35, 12, 10 kDa
Uniprot IDP29466

 


 

Applications

 

ApplicationsSpeciesDilutionPositive Tissue
WBMouse, Rat, Human1: 1000RAW264.7, Raji, MCF-7, NIH/3T3, HeLa, C6, Jurkat

 


 

Background

ASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products . It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20.

 



Storage

 

StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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