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GB13493 Anti -CDK4 Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse CDK4
Isotype: IgG
Purity: Affinity purification
ul:
  • GB13493
  • Servicebio

Description

Product Information

 

DescriptionCDK4 rabbit polyclonal
Protein full namecyclin-dependent kinase 4
SynonymsCDK4, Cell division protein kinase 4, CMM3, cyclin dependent kinase 4, PSK J3
ImmunogenRecombinant protein corresponding to
Mouse CDK4
IsotypeIgG
PurityAffinity purification
Predicted MW.34 kDa
Observed MW.30 kDa
Uniprot IDP11802

 


 

Applications

 

ApplicationsSpeciesDilutionPositive Tissue
WBH Mk1: 1000HeLa, HepG2, pancreas

 


 

Background

CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of the gene have been reported.

 


 

Storage

 

StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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