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GB13495 Anti -iNOS Rabbit pAb Antibody

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 500-730 of human iNOS (NP_000616.3).
Isotype: IgG
Purity: Affinity purification
ul:
  • GB13495
  • Servicebio

Description

Product Information

 

DescriptioniNOS rabbit polyclonal
Protein full nameiNOS
SynonymsNOS, INOS, NOS2A, HEP-NOS, iNOS, NOS2
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 500-730 of human iNOS (NP_000616.3).
IsotypeIgG
PurityAffinity purification
Predicted MW.131kDa
Observed MW.130 kDa
Uniprot IDP35228

 


 

Applications

 

ApplicationsSpeciesDilutionPositive Tissue
WBMouse, Rat1: 500-1: 2000Raw 264.7

 


 

Background

NOS2, also named as iNOS and NOS2A, produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission, antimicrobial and antitumoral activities. NOS2 is a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. iNOS has a very short half-life due to rapid degradation by calpain. iNOS monomer is a direct substrate of calpain I and can be cleaved by calpain I at the canonical CaM-binding site(503-532aa) of iNOS, and then a ~70kD band can be detected by western. This antibody is specific to NOS2.

 


 

Storage

 

StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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