GATA1 is first identified as a member of the GATA transcription factor family, whose members bind the consensus (WGATAR) binding motif. GATA1, a zinc finger DNA-binding transcription factor, plays a critical role in the normal development of hematopoietic cell lineages. The protein contains an N-terminal region that confers transcriptional activity and a C-terminal domain that mediates binding to DNA and other factors. GATA-1 is also implicated in regulating the expression of the erythroid and megakaryocytic-specific genes . GATA1 exists two isoform with the molecular weight 50-55 kDa and 40-45 kDa.