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Anti -P-EIF2α Rabbit PAb for IHC Primary Antibody

Specification:50uL
  • GB13572
  • Servicebio
  • Servicebio

Description

Product Information

 

Description P-EIF2α  rabbit polyclonal
Protein full name EIF2S1
Synonyms Eukaryotic Translation Initiation Factor 2 Subunit Alpha, Eukaryotic Translation Initiation Factor 2 Subunit 1
Immunogen Recombinant protein corresponding to
Mouse P-EIF2α
Isotype IgG
Purity Affinity purification
Subcellular location Cytoplasm, Nucleus
Uniprot ID P05198

 


 

Applications

 

Applications Species Dilution Positive Tissue
IHC Human, Mouse, Rat 1: 500-1: 1000 liver carcinoma

 


 

Background

EIF2S1 is one subunit of the translation initiation factor EIF2, which catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

 


 

Images

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE: This product is intended for research only.

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