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Anti -BOB1 Mouse MAb for Human IHC IF Lymphocyte Markers

Specification:50uL
  • GB14010
  • Servicebio
  • Servicebio

Description

Product Information


Gene Name POU2AF1 OBF1
Protein Name POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)
Human Gene Id 5450
Human Swiss Prot No Q16633
Immunogen Synthesized peptide derived from human BOB.1
Specificity This antibody detects endogenous levels of human BOB.1
Source Mouse/IgG2a, Kappa
Concentration 1 mg/ml
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.




Applications


Applications Species Dilution
IHC、IF Human 1:200-1:500




Background

disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific




Images



Immunohistochemical analysis of paraffin-embedded Classical Hodgkin lymphoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval.

Immunohistochemical analysis of paraffin-embedded Hodgkin lymphoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval.




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.




NOTE: This product is intended for research only.

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