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Anti -CD105 Mouse mAb for immunoblotting IHC IF

Specification:50uL
  • GB14020
  • Servicebio
  • Servicebio

Description

Product Information


Gene Name ENG END
Protein Name Endoglin (CD antigen CD105)
Human Gene Id 2022
Human Swiss Prot No P17813
Immunogen Synthesized peptide derived from human CD105(Endoglin)
Specificity This antibody detects endogenous levels of human CD105(Endoglin)
Source Mouse/IgG1, Kappa
Concentration 1 mg/ml
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.




Applications


Applications Species Dilution
IHC、IF Human 1:200-1:500




Background

Endoglin encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in Endoglin cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Endoglin may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for Endoglin.




Images



Immunohistochemical analysis of paraffin-embedded Placenta. 1, Antibody was diluted at 1:200(4°,overnight). 2, TRIS-EDTA of pH8.0 was used for antigen retrieval.

Immunohistochemical analysis of paraffin-embedded Renal clear cell carcinoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, TRIS-EDTA of pH8.0 was used for antigen retrieval.




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.




NOTE: This product is intended for research only.

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