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Anti -TIMP2 Rabbit pAb Polyclonal antibody

specification:100ul
  • GB11523
  • Servicebio
  • Servicebio

Description

Product Information


Description

TIMP2 rabbit polyclonal

Protein full name

Metalloproteinase inhibitor 2

Synonyms

TIMP2, CSC-21K, DDC8,

TIMP metallopeptidase inhibitor 2

Immunogen

Recombinant protein corresponding to

Mouse TIMP2

Isotype

IgG

Purity

Affinity purification

Subcellular location

secreted

Uniprot ID

P25785P30121




Applications


applications

species

dilution

Positive tissue

IHC,IF

Mouse, Rat

1:1000-1:2000

testis, brain




Background


TIMP2 encoded by Timp2 gene are natural inhibitors of the matrix metalloproteinases (MMP), a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against

metalloproteinases, it has a unique role among TIMP family members in

its ability to directly suppress the proliferation of endothelial cells, which

may be critical to the maintenance of tissue homeostasis by suppressing

the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the

extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF. TIMP2 also plays an important role in hippocampal

function and cognitive function.




Images



Immunohistochemistry analysis of paraffin-embedded mouse testis using TIMP2 (GB11523) at dilution of 1:2000.

Immunohistochemistry analysis of paraffin-embedded mouse brain using TIMP2 (GB11523) at dilution of 1:1400

Immunohistochemistry analysis of paraffin-embedded rat brain using TIMP2 (GB11523) at dilution of 1:1400




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).


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