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GB11181 Anti -Tyrosine Hydroxylase Rabbit pAb

Immunogen: Recombinant protein corresponding to Mouse Tyrosine Hydroxylase 
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11181
  • Servicebio

Description

Product Information

 

Description

Tyrosine Hydroxylase rabbit polyclonal

Protein full name

Tyrosine 3-monooxygenase

Synonyms

TH, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase

Immunogen

Recombinant protein corresponding to Mouse Tyrosine Hydroxylase 

Isotype IgG
Purity Affinity purification
Predicted MW.

62KDa

Observed MW.

62KDa

Subcellular location

Cytoplasm, Axon

Uniprot ID

P24529,P04177

 


 

Applications

 

Applications

Species

Dilution

Positive Tissue

WB

Mouse,Rat

1:1000

U251, N2A, C6

IHC,IF

Human, Mouse, Rat

1:500-1: 1000

striatum,brain

 


 

Background


Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen(O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine(adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene,and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla.Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases(AAAHs).

     


 

Images

 

blob.png

Western blot analysis of Tyrosine Hydroxylase (GB11181) at dilution of 1:1000

Lane 1: U251 cell lysate

Lane 2: N2A cell lysate

Lane 3: C6 cell lysate

blob.png

Immunohistochemistry analysis of paraffin-embedded rat brain striatum using TH(GB11181) at dilution of 1:1000

 

 图片 1.png  

Immunohistochemistry analysis of paraffin-embedded human brain using 

TH (GB11181) at dilution of 1: 1000

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Immunofluorescence analysis of paraffin-embedded mouse brain using TH(GB11181) at dilution of 1:500

 

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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