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Anti -P53 Mouse mAb

Cat. No. GB13029-3

Brand:Servicebio

Price:230.00

Specification: 50μl

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Product Information

 

 

Description P53 mouse monoclonal
Protein full name

Cellular tumor antigen p53

Synonyms

TP53, BCC7, LFS1, P53, TRP53, tumor protein p53,Antigen NY-CO-13

Immunogen

KLH conjugated Synthetic peptide corresponding to Human P53

Isotype IgG
Purity Affinity purification
Subcellular location

Nucleus, Cytoplasm

Uniprot ID P04637

 


 

Applications

 

 

Applications IHC, IF  
Species Human  
Dilution 1:100-1:200  
Positive tissue

Lung cancer, colon cancer

 

 


 

Background

 

 

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.

           


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded human lung cancer using P53 (GB13029-3) at dilution of 1:200.

 

   
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Immunofluorescence analysis of paraffin-embedded human colon cancer using P53 (GB13029-3) at dilution of 1:200.

 

 


 

Storage

 

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. 

 


 

NOTE: This product is intended for research only.