Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using P53 (GB13029-3) at dilution of 1:200.
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Immunofluorescence analysis of paraffin-embedded human colon cancer using P53 (GB13029-3) at dilution of 1:200.
|Storage ||Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
|Storage Buffer ||PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
1.This product is intended for research only.