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Anti-TLR4 Mouse MAb Immune Recognition Antibody

specification:100ul
  • GB12186
  • Servicebio
  • Servicebio

Description

Product Information

 

 

Description

TLR4 mouse monoclonal

Protein full name

Toll-like receptor 4

Synonyms

TLR4, ARMD10, CD284, TLR-4, TOLL,toll like receptor 4

Immunogen

Recombinant protein corresponding to Mouse TLR4 

Isotype IgG
Purity Affinity purification
Subcellular location

Cell membrane

Uniprot ID

Q9QUK6Q9QX05

 


 

Applications

 

 

Applications

IHC, IF

   
Species

Mouse, Rat

   
Dilution

1:500-1:1000

   
Positive tissue

spleen

   

 


 

Background

 

 

TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.It is most well known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and select Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein.

     


 

Images

 

 

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Immunohistochemistry analysis of paraffin-embedded mouse spleen using TLR4 (GB12186) at dilution of 1:1000

   

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Immunohistochemistry analysis of paraffin-embedded rat spleen using TLR4 (GB12186) at dilution of 1:1000

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