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Anti-Tyrosine Hydroxylase Mouse mAb Neuron Monoclonal Antibody

specification:50ul
  • GB12181
  • Servicebio
  • Servicebio

Description

Product Information

 

 

Description

Tyrosine Hydroxylase mouse monoclonal

Protein full name

Tyrosine 3-monooxygenase

Synonyms

TH, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase

Immunogen Recombinant protein corresponding to Mouse Tyrosine Hydroxylase 
Isotype IgG
Purity Affinity purification
Subcellular location

cytoplasm, axon

Uniprot ID

P24529, P04177

 


 

Applications

 

 

Applications

IHC

IF

 
Species

Mouse, Rat

Mouse, Rat

 
Dilution

1:1000-1:3000

1:500-1:2000

 
Positive tissue

Brain, substantia nigra

Mouse striatum

 

 


 

Background

 

 

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen(O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine(adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla.Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases(AAAHs).

     


 

Images

 

 

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Immunofluorescence analysis of paraffin-embedded rat brain using Tyrosine Hydroxylase (GB12181) at dilution of 1:1000

   

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Immunohistochemistry analysis of paraffin-embedded rat substantia nigra using Tyrosine Hydroxylase (GB12181) at dilution of1:3000 

   

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Immunohistochemistry analysis of paraffin-embedded mouse striatum using Tyrosine Hydroxylase (GB12181) at dilution of 1:3000 

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