Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Western blot analysis of HMOX1 (GB11821) at dilution of 1: 1000
Lane 1: Raw264.7 cell lysate
Lane 2: Mouse spleen tissue lysate
Lane 3: Mouse liver tissue lysate
Lane 4: Mouse kidney tissue lysate
Lane 5: Mouse spleen tissue lysate
Immunohistochemistry analysis of paraffin-embedded mouse spleen using HMOX1 (GB11821) at dilution of 1: 1500
Immunohistochemistry analysis of paraffin-embedded rat spleen using HMOX1 (GB11821) at dilution of 1: 1500
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.