Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Immunohistochemistry analysis of paraffin-embedded human gallbladder using FAS (GB12089) at dilution of 1:200
Immunohistochemistry analysis of paraffin-embedded mouse colon using FAS (GB12089) at dilution of 1:400
Immunohistochemistry analysis of paraffin-embedded mouse testis using FAS (GB12089) at dilution of 1:400
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.