Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
Western blot analysis of ERK1/2 (GB12087) at dilution of 1:1000.
Lane 1: Hela cell lysate
Lane 2: HepG2 cell lysate
Lane 3: NIH/3T3 cell lysate
Lane 4: Mouse lung tissue lysate
Lane 5: Mouse kidney tissue lysate
Lane 6: Mouse brain tissue lysate
Lane 7: Rat lung tissue lysate
Lane 8: Rat kindy tissue lysate
Lane 9: Rat brain tissue lysate
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.