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GB14076 Anti -E-cadherin Antibody Mouse mAb

Immunogen: Synthesized peptide derived from human E-Cadherin
Isotype: IgG
Purity: Affinity purification
ul:
  • GB14076
  • Servicebio

Description

Product Information

 

DescriptionE-cadherin mouse polyclonal
Protein full nameEpithelial cadherin
SynonymsCDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1
ImmunogenSynthesized peptide derived from human E-Cadherin
IsotypeIgG
PurityAffinity purification
Subcellular locationCell membrane
Uniprot IDP12830

 


 

Applications

 

ApplicationsSpeciesDilutionPositive Tissue
IHC、IFHuman1: 200-1: 500brain, epidermal carcinoma, hippocampus, liver, pancreas, placenta

 


 

Background
 

cadherin 1(CDH1) Homo sapiens This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

 


 

Storage

 

StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage BufferPBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

 


 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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