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GB11955 Anti -CD146 Rabbit Polyclonal pAb

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse CD146
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11955
  • Servicebio

Description

Product Information


Description

CD146 rabbit polyclonal

Protein full name

Cell surface glycoprotein MUC18

Synonyms

Gicerin, Melanoma cell adhesion molecule, Melanoma-associated antigen MUC18, CD146, Muc18, Mcam, MelCAM, Sendo1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse CD146

Isotype

IgG

Purity

Affinity purification

Predicted MW.

72 kDa

Observed MW.

120 kDa

Uniprot ID

P43121Q8R2Y2Q9EPF2

 


 

Applications

 

Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

blood vessels,

uterus, stomach

 


 

Background
 

MCAM is an immunoglobulin super family member originally described as a cell surface adhesion protein and marker of the progression and metastasis of melanoma . Expression of MCAM protein is seen in vascular endothelial cells, activated T lymphocytes, smooth muscle, and bone marrow stromal cells. Research studies demonstrate increased MCAM expression in endothelial cells from angiogenesis-related disorders, including inflammatorybowel disease, Crohn’s disease, rheumatoid arthritis, tumors, and chronic renal failure. MCAM-expressing human mesenchymal stromal cells in the hematopoietic microenvironment are responsible for maintaining the self-renewal of hematopoietic stem and progenitor cells through direct contact between hMSC and those cells .

 


 

Images

 

image.png

Western blot analysis of CD146 (GB11955) at dilution of 1: 1000

Lane 1: HMVEC cell lysate

Lane 2: HUVEC cell lysate

Lane 3: A375 cell lysate

Lane 4: Mouse blood vessels tissue lysate

Lane 5: Mouse uterus tissue lysate

Lane 6: Mouse stomach tissue lysate

Lane 7: Rat blood vessels tissue lysate

Lane 8: Rat uterus tissue lysate

Lane 9: Rat stomach tissue lysate

 


 

Storage

 

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
 

 

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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